This report discusses the transition of the biopharmaceutical industry to "Biopharma 4.0," which integrates advanced technologies like AI, automation, and data analytics into drug manufacturing. ​ It highlights the critical need for workforce evolution, emphasizing skill gaps among new hires and existing employees, and the importance of public-private partnerships to develop targeted training programs. ​ The Lyon Consortium is presented as a successful example of addressing these challenges through innovative training approaches, interdisciplinary academic programs, and strategic funding initiatives.